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I am MercuryQiu ,Whatsapp / Telegram / Skype : +008619831952837 Telegram / Wickr : mercuryqiu8 Email : mercury@whmulei.com We will offer the best price to you as reference . high quality 100% fast and safe delivery 100% free double customs clearance and after sales service . Looking forward to receive your news . Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole (sodium) is a cyclooxygenase-3 (COX-3) inhibitor What is metamizole sodium used for? An organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic. Metamizole, or dipyrone, is a painkiller, spasm reliever, and fever reliever that also has anti-inflammatory effects. Is metamizole sodium safe? Metamizole is a relatively safe pharmaceutical preparation although it is not completely free from undesirable effects. Among these side-effects, the most serious one that raises most controversy is the myelotoxic effect. It seems that in the past the risk of metamizole-induced agranulocytosis was exaggerated. How often can I take metamizole? Adults and adolescents of 15 years of age or older (> 53 kg) can take up to 1,000 mg metamizole as a single dose, which can be taken up to 4 times daily at intervals of 6–8 hours corresponding to a maximum daily dose of 4,000mg. A clear effect can be expected 30 to 60 minutes after oral administration What is dipyrone used for? Dipyrone has analgesic, spasmolytic, and antipyretic effects and is used to treat pain. Due to a possible risk of agranulocytosis with the use of dipyrone, it has been banned in a number of countries. The most commonly used data for the use of dipyrone are related to adults Can I give my dog Dipyrone? In some countries, dipyrone/metamizole has a veterinary licence for use in dogs and horses as an analgesic, antipyretic, antispasmodic, and (weak) anti-inflammatory drug. Inhibition of COX-3 in the brain and spinal cord is a proposed mechanism of action